Fig. 8

Impact of TSC-Exos on Histology and tendon matrix-related factors. a, h The HE staining of window defect on the Achilles tendon at 2 and 8 weeks post-surgery. Expression of b COL1a1, c COL3a1, d MMP-9, e TIMP-1, f α-SMA, and g fibronectin evaluated at 2 weeks by immunohistochemistry assay. i–n Expression of the above extracellular matrix-related factors after TSC-Exos treatment at 8 weeks. o Quantitative analysis of tendon matrix-related factors at 2 weeks. p Quantitative analysis of tendon matrix-related factors at 8 weeks. Bars, 50 μm. Data are represented as mean ± SD. *, vs control; #, vs GelMA group. *P < 0.05, **P < 0.01, ***P < 0.0001, ^#P < 0.05, ^##P < 0.01, ^###P < 0.0001