From: The potential therapy with dental tissue-derived mesenchymal stem cells in Parkinson’s disease
Type | Study model | Delivery method | Sample size (n) | Number of cells | Treatment duration | Survival time | Neuron improvement | Behaviour test | Mechanism | Authors, year |
---|---|---|---|---|---|---|---|---|---|---|
DPSCs | MPTP-induced Swiss albino mice | IN | 20 | 5 × 105 | 4 weeks | > 4 weeks | TH | Beam traversal test; cylinder test; adhesive removal test | Repair neurogenic niche | Simon et al., 2019 [19] |
DPSCs | Co-culture system of neurons and microglia induced with MPTP | Co-culture | – | 5 × 103 | 2 days | – | Microglia | – | Against neuroinflammation | Gnanasegaran et al., 2017 [20] |
DPSCs | MPTP-induced Old Swiss albino mice | IT | 45 | 1 × 106 | 12 weeks | – | TH | Beam traversal test; cylinder test; adhesive removal test; Buried pellet test; Block test | Immuno-modulation and neuro-restoration | Gnanasegaran et al., 2017 [10] |
DPSCs | Mesencephalic cells of CD1 mice induced with MPP+ or rotenone | Co-culture | – | 5 × 103 | 2 days | – | DA | – | Paracrine, secretion of neurotrophic factors | Nesti et al., 2011 [16] |
Exosome of SHED | 6-OHDA-induced Wistar rats | IN | 16 | 43 × 108 | 17 days | – | TH | Apomorphine-induced rotation behaviour test; CatWalk gait test | Anti-oxidative stress | Narbute et al., 2019 [21] |
SHED | 6-OHDA-induced Wistar rats | IC | 17 | 5 × 105 | 16 weeks | About 16 weeks | DA | Apomorphine-induced rotation behaviour test; rotarod test | Immuno-modulation and neuro-restoration | Zhang et al., 2018 [22] |
Exosome of SHED | ReNcell VM human neural stem cells induced with 6-OHDA | Co-incubation | – | – | 20 h | – | DA | – | Anti-oxidative stress | Jarmalavičiūtė et al., 2015 [17] |
SHED | 6-OHDA-induced Sprague-Dawley rats | IC | 14 | 2 × 105 | 6 weeks | > 6 weeks | DA; TH; CGNs | Methamphetamine-induced rotation test | Paracrine, secretion of neurotrophic factors | Fujii et al., 2015 [23] |
SHED | 6-OHDA-induced Sprague-Dawley rats | IC | 24 | 5 × 105 | 8 weeks | > 6 weeks | DA | Apomorphine-induced rotation behaviour test | Neuro-restoration and paracrine effect | Wang et al., 2010 [24] |