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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Adipose-derived stromal cells modulating composite allotransplant survival is correlated with B cell regulation in a rodent hind-limb allotransplantation model

Fig. 7

Proposed mechanisms involved in ASC modulation of B cell regulation in allotransplantation. ASCs combined with short-term immunosuppressants prolong allotransplant survival by modulating B cell proliferation, enhancing Breg expression, and modulating the secretion of related cytokines such as IL-10 and TGF-β1, resulting in the prolongation of allotransplant survival and the induction of immune tolerance. ASC, adipose-derived stromal cell; APC, antigen-presenting cell; Breg, regulatory B cell

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Stem Cell Research & Therapy

ISSN: 1757-6512