Fig. 6

EPSC-Exos-specific microRNAs inhibited TGF-β1 expression of HDF. a Main miRNAs in EPSC-Exos using qRT-PCR. b A list of predicted binding sites of EPSC-Exos-specific miRNAs and their targets. c, d TGF-β1 mRNA levels of HDF treated with miR-425-5p agomir and miR-142-3p agomir of HDF, respectively. Scale bar = 200 μm. *P < 0.05; ***P < 0.001; mean ± SD; n = 5. Ctrl, control; EGF, epidermal growth factor; EPSC-Exos, epidermal stem cell-derived exosomes; HDF, human dermal fibroblast; TGF-β1, transforming growth factor β-1; IF, immunofluorescence staining