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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: miRNA-126-3p carried by human umbilical cord mesenchymal stem cell enhances endothelial function through exosome-mediated mechanisms in vitro and attenuates vein graft neointimal formation in vivo

Fig. 5

a SPRED-1and PIK3R2 mRNA levels were measured in HUVECs co-cultured with hucMSCs and GFP-hucMSCs and miRNA-126-3p-hucMSCs. b Western blots of PIK3R2 and SPRED-1 protein expression in HUVECs co-cultured with hucMSCs and GFP-hucMSCs and miRNA-126-3p-hucMSCs. c SPRED-1 and PIK3R2 protein levels were higher in the miRNA-126-3p-hucMSCs group than in the hucMSCs or GFP-hucMSCs group. d Representative western blots of AKT phosphorylation and ERK1/2 phosphorylation in HUVECs co-cultured with hucMSCs and GFP-hucMSCs and miRNA-126-3p-hucMSCs. e Quantification of the proliferation rates of HUVECs. f Quantification of the migration area of HUVECs. g Quantification of the migrated cell numbers of HUVECs. i Quantification of the tube length and tubes numbers of HUVECs

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Stem Cell Research & Therapy

ISSN: 1757-6512