Table 1 Different preconditionings of ADSCs and their functions

CO₂ laser combination

Further promote the activation of dermal fibroblast

[21]

GARP silencing

Increase their activation of TGF- β which augment the levels of mtROS

[30]

Nrf2 overexpressing

Promoted granulation tissue formation, angiogenesis, increased the expression of growth factor and decreased proteins related to inflammation and oxidation

[31]

HIF1 α overexpressing

Decrease oxidative stress and DNA damage

[32]

H₂O₂ treated

Reduce apoptosis, more skin flap survival area

[33]

VEGF overexpressing

Inhibit senescence by downregulating SA- β-Gal, recover UV-induced skin injury

[34]

Combined with nanofat

Ablate wrinkles

[35]

Transfected with miR-146a

Angiogenic and anti-inflammatory abilities

[36]

Combined with HA gel

Ablate wrinkles

[37]

Seeded onto collagen scaffolds

Increase dermal thickness and increase ECM

[38]

Combined with fat graft

Ablate wrinkles, promote collagen synthesis and neovascularization

[39]

LLL preconditioning

Increase growth factors secretion, increase dermal thickness

[40]

Engineered to express IFN- β and combined with cisplatin

Migrate to tumor sites and inhibit the growth of melanoma

[41]