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Table 2 Patient-specific iPSC models of hematological disorders

From: Differentiation of human induced pluripotent stem cells into erythroid cells

Authors Disorder iPSC cell source Ref.
Ye et al. 2009 Myeloproliferative disorders (MPDs) iPSCs from peripheral blood CD34+ cells of patients with MPDs [95]
Zou et al. 2011 Chronic granulomatous disease (CGD) iPSCs from patient with X-linked CGD [96]
Kumano et al. 2012 Chronic myelogenous leukemia (CML) iPSCs from imatinib-sensitive CML patient [97]
Chang et al. 2012 α-Thalassemia (α-Thal) iPSCs from α-Thal fibroblasts [98]
Garçon et al. 2013 Diamond Blackfan anemia (DBA) iPSCs from fibroblasts of DBA patient [99]
Bedel et al. 2013 CML iPSCs from CD34+ blood cells isolated from CML patients [100]
Yuan et al. 2013 Paroxysmal nocturnal hemoglobinuria (PNH) iPSCs from adult male dermal fibroblasts [101]
Saliba et al. 2013 Polycythemia vera (PV) iPSCs from 2 polycythemia vera patients carrying a heterozygous and a homozygous mutated JAK2 JAK2V617F [102]
Sakurai et al. 2014 Familial platelet disorder (FPD)/AML iPSCs from three distinct FPD/AML pedigrees [103]
Sun et al. 2014 Sickle cell disease (SCD) iPSCs from patient with SCD mutation [104]
Ye et al. 2014 PV iPSCs from PV patient blood [105]
Xie et al. 2014 β-Thalassemia (β-Thal) iPSCs from patient with β-Thal [106]
Amabile et al. 2015 CML Primary bone marrow cells obtained from a BCR-ABL-positive CML patient [107]
Ge et al. 2015 DBA iPSCs from DBA patients carrying RPS19 or RPL5 mutations [108]
Park et al. 2015 Hemophilia A (HA) iPSCs from patients with chromosomal inversions that involve introns 1 and 22 of the F8 gene [109]
Kotini et al. 2015 Myelodysplastic syndromes (MDS) iPSCs from hematopoietic cells of MDS patients [110]
Huang et al. 2015 SCD iPSCs from adult patients of SCD, which harbor the homozygous βs mutation in the HBB gene [111]
Chang et al. 2015 Severe combined immunodeficiency (SCID) iPSCs from SCID patients with Janus family kinase (JAK3)-deficient cells [112]
Menon et al. 2015 X-linked severe SCID (SCID-X1) iPSCs from SCID-X1 patients [113]
Ingrungruanglert et al. 2015 Wiskott-Aldrich syndrome (WAS) iPSCs from patients with mutations in WASP [114]
Wu et al. 2016 HA iPSCs from peripheral blood from severe HA patients [115]
Pang et al. 2016 HA iPSCs from patients with severe HA [116]
Niu et al. 2016 β-Thal iPSCs from patient with β-Thal [117]
Laskowski et al. 2016 WAS iPSCs from CD34+ hematopoietic progenitor cells of a WAS patient [118]
Doulatov et al. 2017 DBA iPSCs from skin fibroblasts from DBA patient [119]
He et al. 2017 Hemophilia B (HB) iPSCs from HB patient [120]
Chao et al. 2017 Acute myeloid leukemia (AML) iPSCs from AML patient [121]
Kotini et al. 2017 AML iPSC from patients with low-risk MDS (refractory anemia [RA]), high-risk MDS (RA with excess blasts [RAEB]) and secondary AML (sAML or MDS/AML from preexisting MDS) [122]
Miyauchi et al. 2018 CML iPSCs from the bone marrow of two CML-CP patients [123]
Olgasi et al. 2018 HA iPSCs from peripheral blood (PB) CD34+ cells of HA patient [124]
Ramaswamy et al. 2018 HB iPSCs from HB patients [125]
Lyu et al. 2018 HB iPSC from peripheral blood mononuclear cells (PBMNCs) [126]
Cai et al. 2018 β-Thal iPSCs from patient with β-Thal [127]
Wattanapanitch et al. 2018 HbE/β-Thal iPSCs from Skin cells of HbE/β-Thal patients [128]
Sfougataki et al. 2019 β-Thal, SCD, DBA, severe aplastic anemia (SAA), dedicator of cytokinesis 8 (DOCK8) immunodeficiency iPSCs from human bone marrow-derived mesenchymal stromal cells (BM-MSCs) [129]
Kohara et al. 2019 Type IV congenital dyserythropoietic anemia (CDA) iPSCs from CDA patient carrying the KLF1 E325K mutation [130]
Hoffmann et al. 2020 Severe congenital neutropenia (SCN) iPSCs from a SCN patient with a nonsense mutation in the glucose-6-phosphatase catalytic subunit 3 (G6PC3) gene [131]