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Table 1 Point of care devices for bed side separation of SVF

From: Overview of current adipose-derived stem cell (ADSCs) processing involved in therapeutic advancements: flow chart and regulation updates before and after COVID-19

Medical devise

Manufacturer

Closed/semi-closed

Separation method

Proceeded fat quantity (g)

Process duration (min)

Cell yield/g of fat

Device/control (D/C)

Cell viability

D/C or D

References

Celution R 800/CRS

StemSource 900/MB

Cytori Therapeutics, Inc

Closed

Enzymatic

300 g

90

2.41 × 106/NP

NP

[57, 58]

GID SVF-1, SVF-2

GID Group, Inc

Closed

Enzymatic

300 g

90

0.425 × 106 ± 0.047 × 106/0.795 × 106 ± 0.228 × 106

50–84%

[56, 57, 64,65,66,67]

Icellator®

Tissue Genesis, Inc.

Closed

Enzymatic

60

80

0.25–2.0 × 106

64.5 ± 11.4

[57, 68, 69]

Puregraft™

Eurosilicone

Semi-closed

Mechanical

250

100

0.25 × 106 ± 0,07 × 106/0.79 × 106 ± 0.228 × 106

77%

[57]

Stem.pra®

Proteal

Closed

Mechanical

200

110

0.535 × 106 ± 0.209 × 106/0.795 × 106 ± 0.228 × 106

69%

[57]

Cha-Station™

PNC International Co., Ltd.

Semi-closed

Mechanical

Enzymatic

200

90

0.05 × 106

NA

[57, 70]

Sepax®

Biosafe Grop SA

Semi-closed

Mechanical

300

90–120

2.6 ± 1.2 × 105/ML

NA

[55, 57]

UNISTATION™

NeoGenesis

Closed

Not provided

NP

NP

1.1 × 105 ± 1.1 × 105/2.0 × 105 ± 1.7 × 105

NA

[71]

Lipokit MaxStem

Medi-Khan’s

Semi-closed

Enzymatic

NP

88–120

0.35 × 106

50–84

[56, 70]

  1. Processing with the different devices is reported regarding the closed or semi-closed systems and their efficiency to separate SVF in terms of fat quantity, cell yield and viability, and duration. These devices provide all-in-one single-use kit for the SVF separation and might also contain their GMP-grade proteolytic enzymes. NP not provided and, NA not applicable