Fig. 2
Pancreatic weight and the localization of hTERT-MSC following partial pancreatectomy. a Demonstrates the pancreatic weight/body weight ratio in percentage in box plot with each dot representing individual mouse, n = 8. b Localization of hTERT-MSC by human Alu sequence. 0.5 × 106 hTERT-MSC were transplanted via IVR or IPR and the control group with the same volume of MEM intravenously post pancreatectomy (Px). After 8 days, mice were sacrificed and investigated for human Alu sequence. The representative figure shows the number of hTERT-MSC obtained after 8 days of pancreatectomy. After intravenous transplantation (IVR) of hTERT-MSC, majority of MSC were exposed to lung microvasculature and detected in four out of eight lungs. However, few cells homed to the damaged pancreas, only one pancreas out of eight was positive. hTERT-MSC DNA was not detected in other retrieved organs such as the liver, spleen, kidney, heart and in the control group. In contrast, IPR displayed the presence of a significantly higher number of hTERT-MSC. Further, hTERT-MSC DNA remained undetected in undamaged organs. Intravenous route (IVR), intrapancreatic route (IPR) and human telomerase reverse transcriptase mesenchymal stem cells (hTERT-MSC). Data are given as mean ± SEM, *p < 0.05