Fig. 6From: Human embryonic stem cell-derived extracellular vesicles alleviate retinal degeneration by upregulating Oct4 to promote retinal Müller cell retrodifferentiation via HSP90HSP90 in MVs regulates and interacts with Oct4 in Müller cells. After Müller cells were transfected with sh-NC-MVs, sh-HSP90-MVs, pcDNA3.1-MVs, or pcDNA3.1-HSP90-MVs for 48 h, qRT-PCR (a) and western blot (b) were used for analysis of the mRNA and protein expressions of Oct4, and Co-IP for measurement of the interaction between HSP90 and Oct4 after HSP90 was internalized by Müller cells (c); **P < 0.01, ***P < 0.001; MVs, microvesiclesBack to article page