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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Human multipotent mesenchymal stromal cells cytokine priming promotes RAB27B-regulated secretion of small extracellular vesicles with immunomodulatory cargo

Fig. 6

RAB27B silencing reduces the secretion of TSG-6-enriched small exosome-like EVs by primed MS. a RAB27B expression in primed MSC treated with Rab27b siRNA (siRab27b) or scrambled (scr). b NTA of siRab27b and control MSC CM. c NTA of small EVs (< 200 nm) and d Western blot of TSG-6 expression in CM from primed MSC treated with scr and siRab27b. In b, curves represent the average of 3 independent samples. The gray box indicates small EV (sEV)-sized particles (< 200 nm). In other panels, mean ± SD of three individual samples are reported; a, c non-significant differences between groups (paired T-test, p = 0.1, p = 0.2 respectively); in d, (*) represents p ≤ 0.05

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Stem Cell Research & Therapy

ISSN: 1757-6512