Table 1 Renal function parameter measurements at the end of the study (day 45)

Body weight change (g)

61.6 ± 36.2^a

− 23.6 ± 101^b,c

56.7 ± 23

59.7 ± 14

Mean arterial pressure (mmHg)

127 ± 1

201 ± 23

172 ± 30

177 ± 37

CCr (mL/min)

1 ± 0.1

0.85 ± 0.1^d

0.91 ± 0.5^e

1.61 ± 0.5

RCCr (mL/min/day)

0.001 ± 0.003

0.01 ± 0.01

0.005 ± 0.01

0.002 ± 0.008

SCr (mg/dL)

0.6 ± 0.1^f

1.06 ± 0.5

0.87 ± 0.24

0.85 ± 0.13

PT24h (mg/24 h)

10 ± 0.2^g

44.5 ± 22.6

45.8 ± 30

36 ± 21