Fig. 2
MSC-derived PGE2 restrains inflammatory responses in the liver during LPS/D-Gal-induced ALF. a The mRNA levels of pro-inflammatory cytokines (IL-1β, CCL2, iNOS, TNF-α) in the liver in each group (n = 4). b The protein expression levels of NF-κB signaling in each group. c The protein expression levels of TAK1 signaling in each group. d Serum levels of ALT and AST in mice pretreated with TAK1 inhibitor, 5Z-7-ox (n = 4). e Representative HE-stained liver sections and quantitation of necrosis area in each group (n = 4). f Protein levels of TAK1 and NF-κB signaling in each group (*p < 0.05, **p < 0.01, ***p < 0.001)