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Fig. 8 | Stem Cell Research & Therapy

Fig. 8

From: Mesenchymal stem cell-secreted prostaglandin E2 ameliorates acute liver failure via attenuation of cell death and regulation of macrophage polarization

Fig. 8

M2 macrophage polarization depends on EP4. a The mRNA levels of M2 markers (Arg1, Mgl1, Mgl2, and Ym1) in the liver of each group pretreated with EP4i (n = 4). b Serum levels of IL-10 in each group (n = 4). c The mRNA levels of (EP1, EP2, EP3, and EP4) in BMDM under indicated condition (n = 3). d Protein levels of STAT6 and mTOR signaling in BMDM treated with EP4i. e The mRNA levels of M2 markers (Arg1, Mgl1, Mgl2, and Ym1) in BMDM treated with EP4i (n = 3). f Protein levels of STAT6 and mTOR signaling in BMDM knocked down EP4 via siRNA. g The mRNA levels of M2 markers (Arg1, Mgl1, Mgl2, and Ym1) in BMDM knocked down EP4 via siRNA (n = 3) (*p < 0.05, **p < 0.01)

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Stem Cell Research & Therapy

ISSN: 1757-6512