Fig. 2

Administration of Hypo-EVs attenuated OVA-induced chronic airway inflammation in mice. a Schematic illustration of the establishment of mouse chronic allergic airway inflammation model. b Distribution of DIR-labeled EVs in OVA-induced mice lung after tail vein administration (26 day injection and 28 day detected). Representative ex vivo bioluminescence images of mice lungs from different groups (left), and the quantification of the relative fluorescence intensity in the lungs (right; n = 3 from three independent experiments). c Representative photographs of HE- and PAS-stained lung sections from each group (black bar = 200 μm). d, e The inflammatory infiltration and goblet cell hyperplasia were quantified by HE and PAS scores (n = 6). *P < 0.05, **P < 0.01, ***P < 0.001