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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Hypoxic hUCMSC-derived extracellular vesicles attenuate allergic airway inflammation and airway remodeling in chronic asthma mice

Fig. 5

Effect of Hypo-EVs on the expression of TGF-β1-phosphorylated (p)-Smad2/3 in lung tissues and in TGF-β1-treated HLF-1 cells. a Representative Western blots of TGF-β1 and p-Smad2/3 (GAPDH was used as protein loading control) in the lungs from each group (n = 4), and band intensities were normalized against the corresponding GAPDH and the numbers are presented as fold increase over the control group. *P < 0.05, **P < 0.01, ***P < 0.001 vs. PBS group; #P < 0.05 vs. Nor-EV group. b The expression of p-Smad2/3, α-SMA, collogen-1, and GAPDH proteins in TGF-β1-treated HLF-1 cells were determined by Western blotting (n = 3 from three independent experiments). Band intensities were normalized against the corresponding GAPDH (protein loading control) and the numbers are presented as fold increase over the control group. *P < 0.05, ***P < 0.001 vs. TGF-β1 group; #P < 0.05 vs. TGF-β1+Nor-EV group

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Stem Cell Research & Therapy

ISSN: 1757-6512