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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Intramuscular injection of Botox causes tendon atrophy by induction of senescence of tendon-derived stem cells

Fig. 1

a Macroscopic views of the patellar tendon and surrounding musculature at 2 weeks after treatment in the contra-lateral control or Botox injected leg, and the quantitation of tendon width (n = 3, mean ± SD; *p < 0.05). b H&E staining of the patellar tendon in the control and Botox-treated group. Yellow arrows delineate the decreased width of extracellular matrix in the Botox group compared to the control group. c Polarised microscopic examination of the Botox and control group showing the crimps on collagen fibres in Botox group and the quantification of polarised microscopic images (n = 3, mean ± SD; *p < 0.05, **p < 0.005). d Collagen fragmentation as detected by collagen hybridising peptide shows more collagen degeneration in the Botox-injected group

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