Fig. 5

The IFN-γ and poly(I:C)-primed MSCs increased the expression of colonic IDO1 and COX2. Mice with the DSS-induced colitis were sacrificed on day 9 to harvest colon tissues. Representative data of two independent experiments are presented (normal, n = 3; other groups, n = 4). a IHC images of colon sections for IDO1 are shown. Quantification of IDO1-positive cells in the normal mice, the DSS control, the unstimulated MSC-treated, and the primed MSC-treated mice. b The colonic mRNA expression of IDO1, COX2, and PTGES3 increased more in the primed MSC group than in other groups (*p < 0.05, **p < 0.01, ***p < 0.001)