Fig. 8
Differentially secreted cytokines levels between H-CdM and N-CdM. a A volcano plot shows the statistical significance of protein expression changes. The x-axis indicates the log2 of the fold changes for cytokines involved in H-CdM and N-CdM, and the y-axis plots − log10 of their p value. b Clustergrams create a heatmap with dendrograms to indicate all the differentially secreted cytokines between H-CdM and N-CdM. Red and blue indicate relatively high and low expression of the corresponding proteins, respectively. The x-axis indicates differentially expressed cytokines involved in H-CdM and N-CdM, whereas the y-axis indicates the rat’s number (N-CdM group includes Normoxic.1, Normoxic.2, and Normoxic.3, and H-CdM group includes Hypoxic.1, Hypoxic.2, and Hypoxic.3. n = 3/group). N-CdM and H-CdM indicate normoxic- and hypoxic-conditioned medium, respectively