Fig. 1
IDO knockdown partly impairs therapeutic effects of hMuSCs on IBD. a Mice with DSS-induced IBD were administered intravenously with PBS, hMuSCs, ctrl-hMuSCs, or IDO-KD-hMuSCs (2.5 × 105 cells) on day 2. Ctrl-hMuSCs and IDO-KD-hMuSCs were pretreated with IFN-γ (10 ng/ml) and TNF-α (10 ng/ml) for 48 h. Changes in body weight during the entire experiment were shown as the percentage of the initial body weight on day 0. b Colon length of IBD mice was assessed. c H&E staining of the colon sections and histological scores were shown. d IL-6 in the serum of IBD mice was analyzed by ELISA. Five mice per group were used. Scale bars, 100 μm. Results were shown as mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001