Fig. 2
From: Inhibition of TGFβ improves hematopoietic stem cell niche and ameliorates cancer-related anemia
Differentiation of HSCs was suppressed during CRA. a The numbers of peripheral blood white blood cells in control and LLC-bearing mice. b Representative flow cytometric profiles of myeloid cells in the bone marrow. c Representative flow cytometric images of long-term/short-term hematopoietic stem cells (LT/ST-HSC) and multipotent progenitors (MPP) in the bone marrow of control and LLC-bearing mice. d The proportion of LT/ST-HSC and MPP in Lineage− Sca1+ c-kit+ (LSK) cells of control and LLC-bearing mice. e Representative flow cytometric images of common myeloid progenitors (CMP) in the bone marrow of control and LLC-bearing mice. f The ratio of CMP to MPP in the bone marrow of contro and LLC-bearing micel (n = 6). g Representative flow cytometric images of common lymphoid progenitors (CLP) in the bone marrow of control and LLC-bearing mice. h The ratio of CLP to MPP in the bone marrow of control and LLC-bearing mice (n=6). Data are presented as the means ± SD of three independent experiments. *P < 0.05, ***P < 0.001; N.S., no significance; assessed by Student’s t test