Fig. 5

Activation prediction of the oxidative phosphorylation (OXPHOS) pathway and redox-sensitive signalling pathways. a Activation status of the OXPHOS pathway and redox-sensitive signalling pathways. A positive z-score represented the predicted activation and is illustrated in red; a negative z-score represented the predicted inhibition and is illustrated in green. The lighter the colour is, the larger the |z-score| is. The time point labelled in light grey means no valid prediction. b Map of the “oxidative phosphorylation” canonical pathway in the Ingenuity Pathway Analysis database. Proteins labelled in red, green, blue and pink means proteins from clusters 1, 3, 4 and 5 of differentially expressed proteins, respectively. Grey indicates the proteins are not differentially expressed. c Validation of representative proteins from five OXPHOS complexes by western blotting. GAPDH was used as a loading control. d The quantitative results of western blotting from Fig. 5c, data are represented as the means ± standard deviation (SD). *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001. All data were collected at least in triplicate