Fig. 4

hUC-MSCs secrete miR-455-3p and transport it to macrophages to inhibit macrophage secretion of inflammatory factors. a hUC-MSCs transfected with Cy3-labeled miR-455-3p mimics were cocultured with macrophages in Transwell plates (membrane well = 0.4 μm). b, c Abundance of miR-455-3p in exosomes from cell culture medium and macrophages after coculture with hUC-MSCs. d After overexpression of miR-455-3p, the macrophage inflammatory factors were tested. Data are presented as the mean ± SEM (error bar) of at least three independent experiments. *p < 0.05, **p < 0.01, and ***p < 0.001