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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: In vivo monitoring of dynamic interaction between neutrophil and human umbilical cord blood-derived mesenchymal stem cell in mouse liver during sepsis

Fig. 5

Vigorous interactions between HSCs and hUCB-MSCs in the liver of CX3CR1-GFP+/− mice. a Representative time-lapse images showing that HSCs formed extended and retracted dendrites toward hUCB-MSCs. Imaging times (white dotted line: morphology of HSC; yellow dotted line: extended dendrites of HSC; scale bar = 20 μm; Additional file 15: Video S12) are represented. b Representative time-lapse images showing that migratory HSCs engulfed hUCB-MSCs under physiological conditions. Imaging times (scale bar = 20 μm; Additional file 16: Video S13) are represented. c Representative time-lapse images showing the immobile HSCs that engulfed hUCB-MSCs under pathological conditions (including LPS stimulation). Red: CMTPX-labeled hUCB-MSCs (exogenous signal); green: resident CX3CR1+ HSCs (endogenous signal). Imaging times (scale bar = 20 μm; Additional file 17: Video S14) are represented. Data are representative of three independent experiments (original magnification, × 200)

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Stem Cell Research & Therapy

ISSN: 1757-6512