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Fig. 8 | Stem Cell Research & Therapy

Fig. 8

From: Umbilical cord-matrix stem cells induce the functional restoration of vascular endothelial cells and enhance skin wound healing in diabetic mice via the polarized macrophages

Fig. 8

Schematic model of UCMSCs promoting wound healing in diabetic mice. UCMSCs accelerate wound healing and improve angiogenesis in diabetic mice via the remodeling of the macrophage phenotypes. UCMSC-secreted PGE2 plays a crucial role in improving the restoration of vascular endothelial cell dysfunction via the remodeling of macrophage phenotypes, which subsequently improve the local microenvironment of vascular endothelial cells through the secretion of IL-10 and VEGF

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Stem Cell Research & Therapy

ISSN: 1757-6512