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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Mesenchymal stem cell-derived exosomes ameliorate cardiomyocyte apoptosis in hypoxic conditions through microRNA144 by targeting the PTEN/AKT pathway

Fig. 7

Expression levels of PTEN and Rac-1 in hypoxic conditions and modulated by exosomes. A1, A2 Expression levels of PTEN and Rac-1 after growth in hypoxic conditions for 0, 24, 48, or 72 h, determined from by real-time PCR. ###P < 0.001, #P < 0.05; 0-h timepoint was used as control. B1–B3 Expression levels of PTEN and Rac-1 after growth in hypoxic conditions for 0, 24, 48, or 72 h, determined by western blotting. ###P < 0.001, ##P < 0.01, #P < 0.05; 0-h timepoint was used as control. C1–C3 Exosomes regulated expression of PTEN and Rac-1 in the context of hypoxia. ###P < 0.001 vs. normoxia; **P < 0.01 vs. hypoxia. Exo, exosomes; PTEN, phosphatase and tensin homolog deleted on chromosome 10; Rac-1, Ras-related C3 botulinum toxin substrate 1. Statistics calculated based on the results of three repetitions of each experiment

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Stem Cell Research & Therapy

ISSN: 1757-6512