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Fig. 9 | Stem Cell Research & Therapy

Fig. 9

From: Mesenchymal stem cell-derived exosomes ameliorate cardiomyocyte apoptosis in hypoxic conditions through microRNA144 by targeting the PTEN/AKT pathway

Fig. 9

PTEN-specific inhibitor SF1670 increased p-AKT expression levels and modulated H9C2 cell apoptosis in the context of hypoxia. A1, A2 Western blot analysis of p-AKT expression levels under hypoxic growth conditions with addition of varied concentrations of SF1670. B1B4 SF1670 treatment further decreased H9C2 cell apoptosis compared to exosomes or miR-144 mimic treatment in hypoxic conditions. ###P < 0.001 vs. hypoxia; **P < 0.01 vs. hypoxia+miR-144 mimics; *P < 0.05 vs. hypoxia+Exo. PTEN, phosphatase and tensin homolog deleted on chromosome 10; p-AKT, phosphorylated protein kinase B; Exo, exosomes. Statistics calculated based on the results of three repetitions of each experiment

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