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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: AICAR and nicotinamide treatment synergistically augment the proliferation and attenuate senescence-associated changes in mesenchymal stromal cells

Fig. 1

Effect of AICAR and NAM on doubling time and MTT assay of the aging MSCs. a AICAR, NAM, and combination of AICAR+NAM reduce the doubling time of MSCs compared to the control group, from P5 to P10. b Proliferative capacity of MSCs at P10 was determined by MTT assay at the third and seventh day of culture (n = 3 independent experiments). Each bar indicates mean ± SD (*p < .05; **p < .01; ***p < .001; ****p < .0001). Abbreviations: AICAR, 5-aminoimidazole-4-carboxamide ribonucleotide; NAM, nicotinamide; MTT, 3-[4,5-dimethylthiazol-2-yl]2,5-diphenyl tetrazolium bromide

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Stem Cell Research & Therapy

ISSN: 1757-6512