Fig. 4

Upregulation of miR-495 or HOXC6 silencing inhibits cell invasion, migration, and proliferation of CSCs in OSCC. The cells were treated with miR-495 mimic, miR-495 inhibitor, or si-HOXC6. a, b Cell migration ability after different treatments detected by scratch test. c, d Cell invasion ability after different treatments examined by Transwell assay (× 100). e Cell proliferation after different treatments measured by MTT assay. *p < 0.05 vs. the blank group and the NC group. Data (mean ± standard deviation) were analyzed by independent sample t test. The experiment was repeated three times independently