Fig. 1

Distinguishable immune phenotypes between AA patients and HDs. a, b Hypocellularity in bone marrow and pancytopenia in peripheral blood was observed in AA patients. c, d Compared with HDs (n = 39), the percentage of CD8⁺ T cells was significantly increased together with markedly decreased ratio of CD4⁺ T cells to CD8⁺ T cells in AA (n = 49). e The production of interferon-γ (IFN-γ) was significantly increased in CD4⁺ T (CD4⁺IFNγ⁺IL-4⁻, Th1) cells and CD8⁺ T (CD8⁺IFNγ⁺IL-4⁻, Tc1) from AA patients (n = 5). Meanwhile, the ratio of Th1 to Th2 (CD4⁺IFNγ⁻IL-4⁺) and Tc1 to Tc2 (CD8⁺IFNγ⁻IL-4⁺) was also strikingly increased. f The concentrates of IL-6 (HD: n = 8; AA: n = 11), IL-8 (HDs: n = 9; AA: n = 12), TNF-α(HDs: n = 9; AA: n = 10), and IFN-γ(HDs: n = 12; AA: n = 16) in plasma was significantly increased in AA patients, while the concentrates of IL-10 (HDs: n = 9; AA: n = 13) were markedly decreased