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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Multifaceted characterization of the signatures and efficacy of mesenchymal stem/stromal cells in acquired aplastic anemia

Fig. 1

Distinguishable immune phenotypes between AA patients and HDs. a, b Hypocellularity in bone marrow and pancytopenia in peripheral blood was observed in AA patients. c, d Compared with HDs (n = 39), the percentage of CD8+ T cells was significantly increased together with markedly decreased ratio of CD4+ T cells to CD8+ T cells in AA (n = 49). e The production of interferon-γ (IFN-γ) was significantly increased in CD4+ T (CD4+IFNγ+IL-4, Th1) cells and CD8+ T (CD8+IFNγ+IL-4, Tc1) from AA patients (n = 5). Meanwhile, the ratio of Th1 to Th2 (CD4+IFNγIL-4+) and Tc1 to Tc2 (CD8+IFNγIL-4+) was also strikingly increased. f The concentrates of IL-6 (HD: n = 8; AA: n = 11), IL-8 (HDs: n = 9; AA: n = 12), TNF-α(HDs: n = 9; AA: n = 10), and IFN-γ(HDs: n = 12; AA: n = 16) in plasma was significantly increased in AA patients, while the concentrates of IL-10 (HDs: n = 9; AA: n = 13) were markedly decreased

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