Table 1 The different types and roles of lncRNAs in osteogenic differentiation
From: Involvement of the long noncoding RNA H19 in osteogenic differentiation and bone regeneration
Approved symbol | Gene locus | Change in expression | Target(s) | Stem cell types | Refs. |
|---|---|---|---|---|---|
DANCR | 4q12 | Downregulated | miR-1305-Smad 4 axis EZH2, Runx2, OCN p38/MAPK pathway | PDLSCs hBMSCs | |
HOTAIR | 12q13.13 | Downregulated | Wnt/β-catenin pathway miR-17-5p Histone modification | BMSCs | |
MALAT1 | 11q13.1 | Upregulated | Sponging for miR-30 Sponging for miR-214 Sponging for miR-124 Sponging for miR-34c Sponging for miR-204 | hBMSCs VICs | |
MEG3 | 14q32.2 | Upregulated Downregulated | miRNA-543/SMURF1/RUNX2 axis miR-27a-3p/IGF1 axis BMP4 signaling pathway | hDPSCs PDLSCs | |
GAS5 | 1q21 | Upregulated Downregulated | miRNA-498/ RUNX2 axis miR-26-5p/PTEN axis miR-135a-5p/FOXO1 pathway GDF5 and p38/JNK signaling pathway | MSCs HASMCs |