Fig. 3

Conditioned medium derived from EPCs and OGD-ECs co-culture alleviates OPC apoptosis through CXCL12-CXCR4. a, b The concentration of CXCL12 in the supernatant of ECs in each group was detected by ELISA (n = 9, triplicates per group). **P < 0.01 vs. OGD-EC group; ^##P < 0.01 vs. OGD-EC+EPCs or control-siRNA group. c The expression of CXCR4 and CXCR7 in OPCs was detected and analyzed after incubated for 24 with the CM (n = 4, triplicates per group). **P < 0.01 vs. OGD-EC-CM group. d The apoptosis of OPCs was increased with CXCR4 silence (n = 4, triplicates per group). *P < 0.05, **P < 0.01, ***P < 0.001 vs. EC-CM group; ^#P < 0.05 vs. control-siRNA group; ^△P < 0.05 vs. CXCR4-siRNA group. Data were analyzed using Student’s t test