Fig. 4

ADMSC were administered in STZ-induced diabetic mice through IVR and IPR. At day 30, organs were retrieved and weighed. a–d The weights of the heart, kidney, spleen, and lung. No variations were assessed among groups. e A considerable reduction of mean pancreatic weight was noted in STZ and IVR groups compared to IPR. Interestingly, no significant difference was detected between control and IPR body weights. STZ, streptozotocin; IPR, intrapancreatic route; IVR, intravenous route; no STZ and no MSC, control. Data represent the mean ± SEM, n = 11. Value considered significant at p ≤ 0.05, **p ≤ 0.01, and ***p ≤ 0.001