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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Generation of inner ear sensory neurons using blastocyst complementation in a Neurog1+/−−deficient mouse

Fig. 3

Donor stem cells extensively contibute to a complemented Neurog1+/− vestibule. High magnification of the (a, A’) posterior ampulla and (b, B’) utricle in a highly chimeric complemented Neurog1+/− vestibule shows that GFP-labeled donor iPSCs contribute to the near entirely of both structures (n = 1, sample number 111810). GFP co-expresses with TUJ1-labeled vestibular nerves in the vestibular ganglia (VG) (dotted outlines), some MYO6-labeled vestibular hair cells (red), and non-sensory vestibular tissue (white arrows). c Inner ear diagram shows the anatomy of the vestibule with anterior ampulla (AA), lateral ampulla (LA), posterior ampulla (PA), saccule (SAC), and utricle (UT). VG vestibular ganglion. All scales bars are 100 μm

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Stem Cell Research & Therapy

ISSN: 1757-6512