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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Hollow-fiber bioreactor production of extracellular vesicles from human bone marrow mesenchymal stromal cells yields nanovesicles that mirrors the immuno-modulatory antigenic signature of the producer cell

Fig. 4

EV production from hBM-MSCs in the hollow-fiber cell bioreactor system yields nanovesicles of small EV distribution profile. a Histogram plots of nanoparticle size concentration and distribution of the four hBM-MSC donors (N = 4 donors; hBM-MSC-48RB/81RB/55RB/85RB donors) at 3 different time points (days 1, 3, and 25) of EV production (i–iv). Red represents EV material processed at day 1, black represents EV material processed at day 13, and blue represents the final EV product processed at day 25. The mean for each dot represents 5 technical replicates from each hBM-MSC donor. All data was captured on the NanoSight NS300 (Malvern Panalytical) on flow mode. b The EV mode (nm) (i), mean (nm) (ii), and concentration (particles/mL) (iii) are represented as an averaged of the four hBM-MSC donors at each time points

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Stem Cell Research & Therapy

ISSN: 1757-6512