Fig. 4

FGF21- and GLP1-modified MSCs reduced blood glucose and weight in T2DM mice. a Four-week time course of body weight of BKS mice injected i.p. with saline (Con), MSCs, liraglutide, and FGF21- and/or GLP1-transduced MSCs. The arrow position represents the time of cell injection, n=6, *P < 0.05, **P < 0.01, compared to Con. b Gross appearance of BKS mice injected i.p. with saline (Con), MSCs, liraglutide, and FGF21- and/or GLP1-transduced MSCs. c Time course of the fasting blood glucose concentrations of BKS mice injected i.p. with saline (Con), MSCs, liraglutide, and FGF21- and/orGLP1-transduced MSCs, *P < 0.05, **P < 0.01, compared to Con. d Blood glucose concentration from oral glucose tolerance tests in BKS mice injected i.p. with saline (Con), MSCs, liraglutide, and FGF21- and/or GLP1-transduced MSCs; asterisk represents significant differences between groups, P < 0.05, compared to Con. e The serum insulin levels in each group, *P < 0.05, compared to Con