Fig. 7
From: mTOR inhibitor INK128 promotes wound healing by regulating MDSCs
INK128 inhibits differentiation of MDSCs into macrophage in bone marrow and spleen of DM as well as a high-glucose environment. a, b The percentage of macrophage was increased in bone marrow and spleen of DM. c, d INK128 decreased the percentage of macrophage in bone marrow and spleen of DM. e Immunohistochemistry staining showed that macrophage was increased in skin of DM. f INK128 decreased macrophage in skin of DM. g the percentage of macrophage under glucose treatments of 5 mM, 30 mM, and 30 mM + INK128 in vitro. h INK128 promoted the gene expression of S100A8 and S100A9 with glucose treatments. *P < 0.05; **P < 0.01. CON, control mice; DM, diabetic mice; DM + INK128, the diabetic mice treated with INK128