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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Myogenic progenitor cell transplantation for muscle regeneration following hindlimb ischemia and reperfusion

Fig. 3

Characterization of and animal survival after ischemic injury. a Muscle tissue injury after 30 min, 1 h and 2 h of WIT in a murine hindlimb clamp model assessed on POD 3, 7, and 14. Histological signs of regeneration indicated by centrally located cell nuclei were observed on POD 7 and 14 (white circle) in all investigated groups. Prolonged WIT lead to more pronounced ischemic muscle injury. b Animal survival was 100% for animals subjected to a WIT up to 2 h but significantly worsened thereafter. Only 25% of the animals in the 3h WIT group reached the endpoint on POD 14. POD, postoperative day; WIT, warm ischemic time

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Stem Cell Research & Therapy

ISSN: 1757-6512