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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: MSCs derived from amniotic fluid and umbilical cord require different administration schemes and exert different curative effects on different tissues in rats with CLP-induced sepsis

Fig. 2

The administration of MSCs reversed CLP-induced blood plasma changes in the septic rats. The plasma levels of the following proinflammatory cytokines were measured: IL-1β (a), IL-10 (b), IL-6 (c) and TNF-α (d). Compared with the sham treatment, CLP induced the upregulation of these cytokines, while compared with the sepsis treatment, MSC administration downregulated these cytokines. Coagulation activation was assessed by determining PT (e), APTT (f) and fibrinogen levels (g). Compared with the sham treatment, CLP increased the PT and APTT and decreased fibrinogen levels, and these changes were reversed by the administration of MSCs. PT, prothrombin time; APTT, activated partial thromboplastin time. *p < 0.05; ns, no significant difference

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Stem Cell Research & Therapy

ISSN: 1757-6512