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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: GPR4 signaling is essential for the promotion of acid-mediated angiogenic capacity of endothelial progenitor cells by activating STAT3/VEGFA pathway in patients with coronary artery disease

Fig. 2

Effect of different pH environments on the angiogenesis of EPCs derived from non-CAD and CAD individuals. a, b Representative photographs and quantitative analyses of tube formation (a scale bar = 40 μm) and migration (b scale bar = 20 μm) of EPCs incubated in different pH environments after 6 h (n = 6). c Representative photographs and quantitative analyses of EPC-mediated neovascularization derived from non-CAD or CAD in hind limb ischemia. n = 6 per group. A paired t test was performed to determine the statistically significant differences among groups. d HE-, IHC-CD31-, IF-CD31-, and BrdU-stained sections of hind limb ischemia and quantitative analyses of CD31-positive vessels, CD31-positive microvessels and BrdU-positive cells. Scale bar = 20 μm. The data are presented as the mean ± SD. **P < 0.01, ***P < 0.001

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Stem Cell Research & Therapy

ISSN: 1757-6512