Fig. 6
From: The CAD risk locus 9p21 increases the risk of vascular calcification in an iPSC-derived VSMC model
Upregulated expression of most calcification-associated markers in 9p21 KO calcifying VSMCs. a–e R KO-derived calcifying VSMCs showed upregulation expression of markers ALPL (a), CSF1 (b), and RUNX2 (d) in both clones. Expression of CTSK (c) and OPN (e) was either unchanged or downregulated in one clone of the R KO cells. f–l In the NR KO-derived calcifying VSMCs, the markers CSF1 (g) and RUNX2 (k) were upregulated in both clones. ALPL (f), CTSK (h) and OPN (l) were unchanged or downregulated in one clone of the NR KO cells