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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Morusin induces osteogenic differentiation of bone marrow mesenchymal stem cells by canonical Wnt/β-catenin pathway and prevents bone loss in an ovariectomized rat model

Fig. 5

Morusin attenuated bone resorption in OVX rats. a, b Representative three-dimensional reconstruction image and micro-CT analysis of femurs in Sham operated rats, OVX rats, and OVX & Morusin group. Scale bar, 500 μm. c Representative images of HE staining of femurs in Sham operated rats, OVX rats and OVX & Morusin group. Scale bar, 500 μm. Scale bar (enlarged), 250 μm. d RUNX2 and β-catenin immunochemical staining of femurs in Sham operated rats, OVX rats, and OVX & Morusin group. The red arrows indicate the highly expressed region of RUNX2 and β-catenin. Scale bar, 100 μm. OVX, ovariectomized; BV/TV, bone volume/tissue volume; Tb.N, trabecular number; Tb.Th, trabecular thickness; Tb.Sp, trabecular separation; Conn.Dn, connectivity density; SMI, structure model index; RUNX2, runt-related transcription factor 2; N.Ob/B.Pm, osteoblasts number/bone perimeter; Ob.S/BS, osteoblast surfaces/bone surface. We repeated the independent experiment for three times. Means ± SEM. *P < 0.05 and **P < 0.01 in comparison to the control group

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Stem Cell Research & Therapy

ISSN: 1757-6512