Fig. 2

Therapeutic efficacy of MSCs alone or transfected with ANGPT1 in reducing LPS-induced lung inflammation in mice. a Experimental design for in vivo study. C57Bl/6J mice were first challenged by intratracheal instillation of LPS, followed by respective treatment after 30 min. Mice were then sacrificed 3 days after LPS to evaluate therapeutic efficacy. b Number of neutrophils in bronchoalveolar lavage (BAL) fluid were obtained from differential counts via cytospin to evaluate lung airspace inflammation. Group comparisons were analyzed by one-way ANOVA with Bonferroni post hoc test. ^####p < 0.0001, sham/vehicle versus LPS/vehicle group. **p < 0.01 and ****p < 0.0001, LPS/vehicle vs. each treated group