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Table 1 Clinical and biochemical index of the patients at baseline

From: A novel MSC-based immune induction strategy for ABO-incompatible liver transplantation: a phase I/II randomized, open-label, controlled trial

 

MSC (N = 11)

Rituximab (N = 11)

P value

Gender (male)(%)

9 (81.8%)

10 (90.9%)

1.000

Age (years)

48.64 ± 7.94

43.64 ± 13.25

0.296

WBC (× 109)

7.32 (3.86–11.60)

9.29 (6.69–15.66)

0.365

PLT (×109/L)

71.00 (47.00–90.00)

104.00 (75.00–201.00)

0.056

AST (U/L)

69.00 (21.00–111.00)

97.00 (53.00–180.00)

0.217

ALT (U/L)

30.00 (9.00–94.00)

99.00 (18.00–233.00)

0.171

ALB (g/L)

32.20 (30.80–35.80)

34.20 (33.20–36.20)

0.773

TBIL (umol/L)

420.73 (38.45–541.73)

590.07 (202.35–702.68)

0.116

ALP (U/L)

99.00 (95.00–124.00)

99.00 (71.00–116.00)

0.478

GGT (U/L)

49.00 (33.00–77.00)

51.00 (42.00–75.00)

1.000

PT (s)

25.60 (20.60–37.60)

33.20 (29.10–38.80)

0.251

INR

2.31 (1.75–3.67)

3.17 (2.71–3.98)

0.270

CREAT (umol/L)

76.00 (45.00–114.00)

71.00 (56.00–174.00)

0.748

BUN (mmol/L)

7.73 (5.01–9.16)

5.35 (3.18–15.44)

0.699

IgM

8.00 (8.00–32.00)

8.00 (8.00–16.00)

0.898

IgG

16.00 (8.00–32.00)

32.00 (2.00–64.00)

0.478

CPS score

11.82 ± 1.66

11.46 ± 1.57

0.604

MELD score

31.00 (30.00–40.00)

40.00 (32.00–40.00)

0.217

Donor age (years)

41.09 ± 15.78

42.73 ± 8.63

0.767

Cold ischemia time(h)

6.00 (6.00–7.50)

6.00 (4.72–7.00)

0.270

Operation time (min)

443.64 ± 41.65

425.64 ± 60.23

0.425

Anhepatic phase time (min)

45.00 (42.00–55.00)

43.00 (40.00–55.00)

0.847

Intraoperative blood loss (mL)

1500.00 (1500.00–2400.00)

1500.00 (1000.00–2000.00)

0.365

Blood transfusion volume

 RBC (U)

12.00 (6.00–16.00)

9.50 (7.50–16.00)

0.797

 FFP (mL)

2400.00 (2100.00–3600.00)

3050.00 (2000.00–4000.00)

0.606

 Cryo (U)

28.00 ± 15.28

36.05 ± 8.08

0.138

  1. Abbreviations: MSC mesenchymal stem cell, WBC white blood cell, PLT platelet, AST aspartate aminotransferase, ALT alanine aminotransferase, ALB albumin, TBIL total bilirubin, ALP alkaline phosphatase, GGT gamma-glutamyl transferase, PT prothrombin time, INR international normalized ratio, CREAT creatinine, BUN blood urea nitrogen, CPS Child-Pugh score, MELD model for end stage liver disease, RBC red blood cell, FFP fresh frozen plasma, Cryo cryoprecipitate