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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: GATA-targeted compounds modulate cardiac subtype cell differentiation in dual reporter stem cell line

Fig. 2

Subclass of structure-dependent GATA4/NKX2-5 synergy inhibitors demonstrate a substantial increase of %venGFP+ cells. a Electrostatic distribution of compound 3i-1000 partially resembles the electrostatic field of an acetyl lysine residue. b Subclass of GATA4/NKX2-5 synergy inhibitors 3i-1000, 3i-1047, 3i-1148, and 3i-1194 contain the acetyl lysine-like domain and increased the %venGFP+ cells in the spontaneous differentiation assay (n = 3–26). c Highly potent GATA4/NKX2-5 synergy inhibitors 3i-0662, 3i-1037, 3i-1043, and 3i-1165 are not structurally aligned with the acetyl lysine-like domain and do not activate ventricular gene expression (n = 2–3). d Low affinity GATA4/NKX2-5 synergy inhibitors 3i-2042, 3i-2043, and 3i-2045 demonstrated a trend to increase the number of venGFP+ cells in the differentiation assay (n = 2)

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Stem Cell Research & Therapy

ISSN: 1757-6512