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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Mesenchymal stem/stromal cells as a valuable source for the treatment of immune-mediated disorders

Fig. 1

Two mechanisms suggested for recruiting endogenous MSC after tissue injury. a Special mediators (e.g., cytokines and growth factors) secreted by the injured tissue can stimulate recruitment of MSC from BM to injured sites through circulation. b Otherwise, MSC can be recruited from within tissues to the injured sites by migration within the stroma or through micro-capillaries. Mesenchymal stem/stromal cell (MSC); bone marrow (BM); stem cell factor (SCF); stromal cell-derived factor-1 (SDF-1); granulocyte colony-stimulating factor (G-CSF)

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