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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: MSC-derived small extracellular vesicles overexpressing miR-20a promoted the osteointegration of porous titanium alloy by enhancing osteogenesis via targeting BAMBI

Fig. 7

Bioinformatic analysis and verification of the targets of miR-20a. a Three online prediction tools such as miRWalk, Starbase and miRDB were applied for selecting the potential targets of miR-20a. Venn diagram was showed for screening of BAMBI. b The gene expression of BAMBI after treated with sEV-20a. c The predicted binding sites of miR-20a in the 3′-UTR of BAMBI-WT mRNA. d Luciferase report assay showed the luciferase activity of BAMBI-WT and BAMBI-Mu treated by miR-20a. Negative control (NC) was used as the control vector ( *p < 0.05)

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