Table 2 Outcomes (engraftment and GVHD) of included studies
First author, year, and country | ANC ≥ 0.5 × 109/L (days) | PLT ≥ 20 × 109/L (days) | aGVHD (events/total) | cGVHD (events/total) |
|---|---|---|---|---|
Ning, 2008, China [24] | 16.25 ± 2.602 VS 15.25 ± 2.602 | PLT > 50, 30 (16–45) VS 27 (15–64) | Grade I-IV, 4/9 VS 11/15; grade II-IV, 1/9 VS 8/15; grade I-II, 4/9 VS 11/15; grade III-IV, 0/9 VS 0/15 | Lim, 1/7 VS 1/14; Ext, 0/7 VS 3/14 |
Ghavamzad, 2010, Iran [27] | 14 VS 13, p = 0.16 | 16/15, p = 0.34 | Grade III-IV, 6/25 VS 4/23; P = 0.73 | NA |
Liu, 2011, China [22] | NA | 19.5 (8–52) VS 20 (10–80) | Grade I-IV, 16/27 VS 16/27; grade II-IV, 13/27 VS 9/27; grade I-II, 16/27 VS 15/27; grade III-IV, 0/27 VS 1/27 | Lim, 9/27 VS 11/24; Ext, 4/27 VS 4/24 |
Wu, 2013b, China [28] | 12 ± 2.31 VS 25.5 ± 7.94, p = 0.003* | 30 (20–45) VS 73 (42–135), p = 0.004* | Grade I-IV, 4/8 VS 8/12; grade II-IV, 1/8 VS 3/12; grade I-II, 4/8 VS 7/12; grade III-IV, 0/8 VS 1/12 | Lim, 1/8 VS 1/12; Ext, 0/8 VS 4/12 |
Mareika, 2016, Belarus [29] | 19 (12–20) VS 24 (16–45), p = 0.09 | 18 (10–44) VS 23 (16–144), p = 0.05 | Grade II-IV, 1/10 VS 3/12; grade III-IV, 0/10 VS 3/12 | Ext, 1/10 VS 4/12 |
Xiang, 2017, China [13] | 12.25 ± 1.59 VS 15.96 ± 2.20, p = 0.000* | 15.42 ± 2.59 VS 16.02 ± 2.86, p = 0.382 | NA | Overall, 1/32 VS 7/32; P = 0.023 |
Ball, 2007, Netherlands [16] | 12 (10–17) VS 13 (9–28), p = 0.15 | 10 (9–18) VS 13 (9–100), p = 0.13 | Grade I-IV, 2/14 VS 14/47; grade I-II, 2/14 VS 12/47; grade III-IV, 0/14 VS 2/47 | Lim, 1/14 VS 4/47; Ext, 0/14 VS 2/47 |
Daganzo, 2009, Spain [30] | 12 (10–31) VS 10 (9–36), p: NS | 44 (27–98) VS 32 (13–97), p: NS | Grade I-IV, 5/9 VS 29/46; grade II-IV, 4/9 VS 11/46; grade I-II, 5/9 VS 23/46; grade III-IV, 0/9 VS 6/46 | Lim, 1/8 VS 8/33; Ext, 0/8 VS 3/33 |
MacMillan, 2009, USA [31] | 19 (8–28) VS 15 (11–30), p = 0.55 | PLT > 50, 53 (36–98) VS 69 (31–129); p = 0.55 | Grade II-IV, 3/8 VS 5/23 | Overall, 0/8 VS 4/23; p = 0.23 |
Baron, 2010, Belgium [32] | ANC > 1, 10 VS 9; p = 0.2 | PLT > 100, 11 VS 13; p = 0.7 | Grade II-IV, 9/20 VS 9/16; p: NS | NA |
Hou, 2010, China [33] | 12 (11–20) VS 11.5 (11–21) | 19 (11–46) VS 19 (10–78), p > 0.05 | NA | NA |
Bernardo, 2011, Italy [15] | 30 (17–42) VS 28 (13–44) | 32 (14–85) VS 36 (18–91), p: NS | Grade I-IV, 5/13 VS 21/39; grade II-IV, 4/13 VS 16/39; grade I-II, 5/13 VS 11/39; grade III-IV, 0/13 VS 10/39 | Lim, 0/10 VS 1/30; Ext, 0/10 VS 2/30 |
Lee, 2013, Korea [14] | 19 (16–21) VS 24 (17–34), p = 0.03* | 47 (33–80) VS 57 (41–100), P = 0.26 | Grade I-IV, 5/7 VS 5/8; grade I-II, 4/7 VS 5/8; grade III-IV, 1/7 VS 0/8 | Ext, 1/7 VS 3/6; P = 0.27 |
Wu, 2013a, China [34] | 11 (7–13) VS 25 (19–39), p = 0.02* | 32 (22–41) VS 69 (55–113), p = 0.01* | Grade I-IV, 2/5 VS 6/9; grade I-II, 2/5 VS 5/9; grade III-IV, 0/5 VS 1/9 | Lim, 1/5 VS 3/9; Ext, 0/5 VS 1/9 |
Xiao, 2013, China [35] | 12.143 ± 2.743 VS 20.5 ± 7.653 | 8.714 VS 19.500, p < 0.01* | NA | Overall, 0/7 VS 3/8 |
Wang, 2015, China [36] | 17 (14–21) VS 21 (19–25), p = 0.007* | 19 (18–22) VS 21 (20–26), p = 0.024* | Grade I-IV, 2/7 VS 3/7; grade I-II, 2/7 VS 2/7; grade II-IV, 2/7 VS 3/7; grade III-IV, 0/7 VS 1/7 | Lim, 2/7 VS 2/7; Ext, 1/7 VS 3/7 |
Zhang, 2015, China [37] | 12 (9–22) VS 15 (9–26), p = 0.041* | 15 (9–38) VS 16 (11–46), p = 0.78 | Grade I-IV, 11/22 VS 16/27; grade II-IV, 3/22 VS 5/27 | Lim, 3/20 VS 5/27; Ext, 1/20 VS 9/27 |
Kang, 2017, China [38] | 14 VS 15, p = 0.691 | 20 VS 19, p = 0.525 | Grade I-IV, 15/34 VS 12/13; grade I-II, 9/34 VS 8/13; grade III-IV, 6/34 VS 4/13 | Lim, 5/34 VS 2/13; Ext, 4/34 VS 2/13 |
Ghavamzad, 2017, Iran [39] | NA | 27.2 (22–31) VS 36.6 (22–50), p = 0.26 | Overall, 23/41 VS 19/29 | Overall, 9/41 VS 11/29 |