Fig. 6
From: TRPC7 regulates the electrophysiological functions of embryonic stem cell-derived cardiomyocytes
Knockdown of TRPC7 did not affect the activity of HCN in mESC-CMs. Representative IHCN recorded from mESC-CM a knockdown control group and b TRPC7 knockdown group, respectively. c I-V curve of HCN calculated from a and b. TRPC7 knockdown did not change the amplitude of IHCN. Data were presented as mean ± SEM (n = 15 cells; cells were from 3 independent batches of differentiation). Representative IHCN recorded from a mESC-CM knockdown control d before and e after adding Cs+, a specific blocker of HCN channels. f I-V curve of HCN calculated from d and e. The amplitude of current decreased after Cs+ application, indicating the current measured was IHCN