Fig. 2

Sepsis-induced heart dysfunction is caused by mitochondrial injury, which is reversed by huMSCs-exo. a Representative TUNEL staining for the detection of apoptotic cardiomyocytes (green dots indicated by arrows); nuclei were stained with DAPI (blue). b After CLP for 12 h and treatment with huMSCs-exo, the mitochondrial architecture was observed under transmission electron microscopy (TEM) and imaged at a × 10,000 magnification (scale bars, 2 μm); the box in the image is a local magnification. c The cardiomyocyte ATP content in mice 12 h after the CLP and treatment with huMSC-exo was measured using a bioluminescent assay system; ***p < 0.001 vs. sham group, ###p < 0.001 vs. CLP 12 h group